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Journal / Medicine / Användning av nikotin i en kiseldioxidexponerad…
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Användning av nikotin i en kiseldioxidexponerad musmodell för att främja lungepitel-mesenkymal övergång
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Användning av nikotin i en kiseldioxidexponerad musmodell för att främja lungepitel-mesenkymal övergång

Article DOI: 10.3791/65127-v • 06:12 min • March 3rd, 2023
March 3rd, 2023 •
*1,2,3,4, *1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4
1Key Laboratory of Industrial Dust Control and Occupational Health of the Ministry of Education, Anhui University of Science and Technology, 2Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Anhui University of Science and Technology, 3Anhui Province Engineering Laboratory of Occupational Health and Safety, 4School of Medicine, Department of Medical Frontier Experimental Center, Anhui University of Science and Technology
* These authors contributed equally

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Denna studie beskriver en musmodell för att studera den synergistiska effekten av nikotin på progressionen av lungfibros i experimentella silikosmöss. Musmodellen med dubbel exponering simulerar det patologiska förloppet i lungan efter samtidig exponering för nikotin och kiseldioxid. De beskrivna metoderna är enkla och mycket reproducerbara.

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Nikotin kiseldioxid lungepitel-mesenkymal övergång silikos musmodell kroniskt nikotinintag upprepad exponering för kiseldioxid lungfibros cigarettrök subkutan injektion kristallint kiseldioxidpulver inhalationsexponering dubbelexponerad musmodell
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