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Journal / Cancer Research / 急性リンパ芽球性白血病患者由来異種移植マウスモデルを用いたキメラ抗原受容体T細胞関連毒性の評価…
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JoVE Journal Cancer Research
急性リンパ芽球性白血病患者由来異種移植マウスモデルを用いたキメラ抗原受容体T細胞関連毒性の評価
Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
Journal (Cancer Research)
Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
Thawing and Culturing Cryopreserved Blood for Cytokinesis Assay (Video) | JoVE
Journal (Cancer Research)
Thawing and Culturing Cryopreserved Blood for Cytokinesis Assay (Video) | JoVE
 
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急性リンパ芽球性白血病患者由来異種移植マウスモデルを用いたキメラ抗原受容体T細胞関連毒性の評価

Article DOI: 10.3791/64535-v • 06:08 min • February 10th, 2023
February 10th, 2023 •
1,2,3,4,5, 1,2, 1,2, 6, 6, 1,2, 1,2, 6, 1,2,6
1T Cell Engineering Laboratory, Mayo Clinic, Rochester, 2Division of Hematology, Mayo Clinic, Rochester, 3Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, 4Department of Molecular Medicine, Mayo Clinic, Rochester, 5Regenerative Sciences PhD Program, Mayo Clinic, Rochester, 6Department of Immunology, Mayo Clinic, Rochester

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ここでは、急性リンパ芽球性白血病患者由来の異種移植片モデルを、CD19標的キメラ抗原受容体T細胞関連毒性を評価および監視するための戦略として使用するプロトコルについて説明します。

Tags

がん研究、第192号、CART細胞、CART細胞関連毒性、患者由来異種移植片(PDX)モデル、がん治療、 in vivo 前臨床モデル
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