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Journal / Bioengineering / 使用成熟的人诱导多能干细胞来源心肌细胞单层进行高通量心脏毒性筛选…
JoVE Journal
Bioengineering

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JoVE Journal Bioengineering
使用成熟的人诱导多能干细胞来源心肌细胞单层进行高通量心脏毒性筛选
Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy
Journal (Bioengineering)
Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy
Use of Micro X-ray Computed Tomography with Phosphotungstic Acid Preparation to Visualize Human Fibromuscular Tissue
Journal (Bioengineering)
Use of Micro X-ray Computed Tomography with Phosphotungstic Acid Preparation to Visualize Human Fibromuscular Tissue
 
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使用成熟的人诱导多能干细胞来源心肌细胞单层进行高通量心脏毒性筛选

Article DOI: 10.3791/64364-v • 14:03 min • March 24th, 2023
March 24th, 2023 •
1, 2, 3, 1, 1
1Frankel Cardiovascular Regeneration Core Laboratory, Cardiovascular Medicine-Internal Medicine, University of Michigan, Ann Arbor, 2CAIRN Research, 3StemBioSys, Inc.

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人诱导多能干细胞来源的心肌细胞（hiPSC-CMs）为使用动物进行临床前心脏毒性筛查提供了一种替代方案。hiPSC-CMs在临床前毒性筛查中广泛采用的一个限制是细胞的不成熟，胎儿样表型。这里介绍的是用于hiPSC-CMs稳健和快速成熟的方案。

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