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Journal / Neuroscience / 毫秒氢/氘交换质谱法用于生理条件下α-突触核蛋白结构动力学的研究…
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Neuroscience

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JoVE Journal Neuroscience
毫秒氢/氘交换质谱法用于生理条件下α-突触核蛋白结构动力学的研究
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毫秒氢/氘交换质谱法用于生理条件下α-突触核蛋白结构动力学的研究

Article DOI: 10.3791/64050-v • 08:40 min • June 23rd, 2022
June 23rd, 2022 •
1, 1
1Living Systems Institute, Department of Biosciences, University of Exeter

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Summary
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单体α-突触核蛋白的结构集合影响其生理功能和理化性质。本方案描述了如何进行毫秒氢/氘交换质谱和随后的数据分析，以确定在生理条件下这种内在无序蛋白质的单体的构象信息。

Tags

神经科学，第184期，α-突触核蛋白，内在紊乱，毫秒氢/氘交换质谱，动态结构生物学
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