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Neuroscience
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JoVE Journal Neuroscience

Molekylær modulering af lentivirus-leverede specifikke shRNA'er i endoplasmatisk retikulum stressede neuroner

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats

Journal (Neuroscience)

Activity-based Training on a Treadmill with Spinal Cord Injured Wistar Rats

Measuring the Influence of Magnetic Vestibular Stimulation on Nystagmus, Self-Motion Perception, and Cognitive Performance in a 7T MRT

Journal (Neuroscience)

Measuring the Influence of Magnetic Vestibular Stimulation on Nystagmus, Self-Motion Perception, and Cognitive Performance in a 7T MRT

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Molekylær modulering af lentivirus-leverede specifikke shRNA'er i endoplasmatisk retikulum stressede neuroner

Article DOI: 10.3791/61974-v • 10:50 min • April 24th, 2021

April 24th, 2021 •

Carolina Morales¹, Mariano Bisbal¹, Mariana Bollo¹

¹Instituto de Investigación Médica M y M Ferreyra, INIMEC-CONICET, Universidad Nacional de Córdoba

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I denne undersøgelse slås ekspressionen ned af to nedstrøms signalkomponenter i PERK-vejen, det cytobeskyttende calcineurin og det pro-apoptotiske CHOP, ved hjælp af specifikke shRNA'er. På modsatte måder modulerer disse følsomheden af primære kortikale neuroner til neuritatrofi efter induktion af endoplasmatisk retikulumstress.

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Neurovidenskab udgave 170 Neurodegenerative lidelser Ufoldet proteinrespons (UPR) Proteinkinase RNA [PKR]-lignende ER-kinase (PERK) Gangliosid GM2 Calcineurin (CN) CHOP (CCAAT/forstærkerbindende protein homologt protein) Mikrotubulusassocieret protein 2 (MAP2)

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