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Journal / Cancer Research / Beoordeling van Cellular Target Engagement door…
JoVE Journal
Cancer Research

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JoVE Journal Cancer Research
Beoordeling van Cellular Target Engagement door SHP2 (PTPN11) Phosphatase Inhibitors
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Beoordeling van Cellular Target Engagement door SHP2 (PTPN11) Phosphatase Inhibitors

Article DOI: 10.3791/61457-v • 08:45 min • July 17th, 2020
July 17th, 2020 •
1, 1, 1, 1, 1, 1
1Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute

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De mogelijkheid om doelbetrokkenheid door kandidaat-remmers in intacte cellen te beoordelen is cruciaal voor de ontdekking van geneesmiddelen. Dit protocol beschrijft een 384 goed formaat cellulaire thermische verschuiving test die betrouwbaar detecteert cellulaire doel betrokkenheid van remmers gericht op ofwel wild-type SHP2 of de oncogene varianten.

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Deze maand in JoVE cellulaire target engagement test cellulaire thermische verschuiving eiwit tyrosine fosfatase Src-homologie 2 domein-bevattende fosfatase SHP2 PTPN11 allosterische remmer klein molecuul antikanker drug drug ontdekking eiwit drug interactie
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