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Cancer Research

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JoVE Journal Cancer Research
Ortotopisk transplantation af brysttumorer som prækliniske modeller for brystkræft
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Ortotopisk transplantation af brysttumorer som prækliniske modeller for brystkræft

Article DOI: 10.3791/61173-v • 07:45 min • May 18th, 2020
May 18th, 2020 •
*1,2,3, *1,2,3, 1,2,3, 1,2,3, 1,2,3, 1,2,3
1Department of Molecular and Cellular Biology, Baylor College of Medicine, 2Lester and Sue Smith Breast Center, Baylor College of Medicine, 3Dan L. Duncan Cancer Center, Baylor College of Medicine
* These authors contributed equally

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Patient-afledte xenograft (PDX) modeller og transplanterbare genetisk manipulerede musemodeller trofast rekapitulere menneskelige sygdomme og er foretrukne modeller for grundlæggende og translationel brystkræft forskning. Her, en metode er beskrevet til ortotopisk transplantere brysttumor fragmenter i bryst fedt pad til at studere tumor biologi og evaluere lægemiddelrespons.

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Kræftforskning brystkræft præklinisk model bryst fedt pad transplantation tumorbiologi lægemiddelrespons biomarkør
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