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Journal / Genetics / 生体内で単純および複雑な DNA 損傷に対する細胞応答を研究するレーザー…
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Genetics

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JoVE Journal Genetics
生体内で単純および複雑な DNA 損傷に対する細胞応答を研究するレーザー Microirradiation
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生体内で単純および複雑な DNA 損傷に対する細胞応答を研究するレーザー Microirradiation

Article DOI: 10.3791/56213-v • 10:44 min • January 31st, 2018
January 31st, 2018 •
*1, *2, 2, 2, 2, 2,3,4, 1
1Department of Biological Chemistry, School of Medicine, University of California, Irvine, 2Beckman Laser Institute and Medical Clinic, University of California, Irvine, 3Department of Developmental and Cell Biology, School of Biological Sciences, University of California, Irvine, 4Department of Biomedical Engineering and Surgery, University of California, Irvine
* These authors contributed equally

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このプロトコルの目標はレーザー microirradiation を使用してさまざまな種類の比較的単純な鎖切断と被害サイト体内に DNA 損傷シグナル伝達と修復因子アセンブリを勉強する、複雑な損傷を含む DNA の損傷を誘発する方法を記述することです。.

Tags

遺伝学、問題 131、microirradiation レーザー、レーザー医学、DNA 損傷、DNA 損傷応答、DNA 修復、ポリ (adp-リボース) ポリメラーゼ (PARP)、複雑な損傷は、ストランドの休憩、基本ダメージ
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