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Journal / Immunology and Infection / Inductie van verlamming en visuele systeem schade …
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Inductie van verlamming en visuele systeem schade in muizen door T cellen specifiek voor Neuromyelitis Optica Autoantigen Aquaporin-4
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Inductie van verlamming en visuele systeem schade in muizen door T cellen specifiek voor Neuromyelitis Optica Autoantigen Aquaporin-4

Article DOI: 10.3791/56185-v • 09:29 min • August 21st, 2017
August 21st, 2017 •
*1,2, *1, 1,2, 3, 3, 1, 4, 1,2
1Department of Neurology, University of California, 2Program in Immunology, University of California, 3Department of Neurology and Neurological Sciences, Stanford University, 4Department of Pathology, Stanford University
* These authors contributed equally

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Hier presenteren we een protocol om te veroorzaken verlamming en opticospinal ontsteking door overdracht van aquaporin-4 (AQP4)-specifieke T-cellen van de AQP4- / - muizen in WT muizen. Daarnaast tonen we hoe met seriële optische coherentie tomografie controleren visuele systeem dysfunctie.

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Immunologie kwestie 126 neuromyelitis optica aquaporin-4 stroom cytometry T cel adoptief overdracht CNS autoimmuniteit optische coherentie tomografie
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