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Immunology and Infection

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JoVE Journal Immunology and Infection
Etablering af en High-throughput Opsætning til screening små molekyler, der modulerer c-di-GMP Signalering i
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Etablering af en High-throughput Opsætning til screening små molekyler, der modulerer c-di-GMP Signalering i

Article DOI: 10.3791/54115-v • 11:31 min • June 30th, 2016
June 30th, 2016 •
1, 1, 1
1Division of Molecular Microbiology, College of Life Sciences, University of Dundee

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Denne artikel beskriver high-throughput assay, som er blevet etableret for at screene store biblioteker af små molekyler for deres potentielle evne til at manipulere cellulære niveauer af cyclisk di-GMP i Pseudomonas aeruginosa, hvilket giver en ny kraftfuldt værktøj til antibakteriel lægemiddelforskning og forbindelse testning.

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Immunologi Cyklisk di-GMP signalering high-throughput screen grønt fluorescerende protein reporter antibiotikaresistens biofilmdannelse,
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