Spain - Consejo Superior de Investigaciones Cientificas and Universidad Miguel Hernandez 1 article published in JoVE Neuroscience Monitoring Fine and Associative Motor Learning in Mice Using the Erasmus Ladder Alice Staffa*1, Moumita Chatterjee*1, Ariadna Diaz-Tahoces*1, Felix Leroy1, Isabel Perez-Otaño1 1Instituto de Neurociencias, Sant Joan d’Alacant, Spain - Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández This article presents a protocol that allows a non-invasive and automated assessment of fine motor performance, as well as adaptive and associative motor learning upon challenges, using a device called the Erasmus Ladder. Task difficulty can be titrated to detect motor impairment ranging from major to subtle degrees.