Chapter 10

Cell Cycle and Division

What is the Cell Cycle?
The cell cycle refers to the sequence of events throughout a typical eukaryotic cell’s life. The somatic cell cycle involves two stages:…
Genomic DNA in Prokaryotes
10.2: Genomic DNA in Prokaryotes
The prokaryotic genome consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The…
Binary Fission
10.3: Binary Fission
Fission refers to the division of a single entity into two, or more, parts and the regeneration of those parts into separate entities that resemble…
Genomic DNA in Eukaryotes
10.4: Genomic DNA in Eukaryotes
Eukaryotes have large genomes compared to prokaryotes. In order to fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly…
Interphase
10.5: Interphase
The processes of the cell cycle occur over a period of 24 hours and in two distinguishable stages: Interphase, which constitutes three phases of the…
Mitosis and Cytokinesis
10.6: Mitosis and Cytokinesis
In eukaryotic cells, the cell's cycle—the division cycle—is divided into distinct, coordinated cellular processes that…
Positive Regulator Molecules
10.7: Positive Regulator Molecules
The cell cycle is regulated at distinct checkpoints that monitor the integrity of the process—including growth of the cell to the appropriate…
Negative Regulator Molecules
10.8: Negative Regulator Molecules
Several proteins negatively regulate the cell cycle to prevent replication from occurring before cells are ready. DNA damage At any stage of the…
Live Cell Imaging
10.9: Live Cell Imaging
Live cell imaging via time-lapse fluorescent microscopy is one of the most common methods of studying mitosis in labs today.…
Neuroscience: Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells
10.10: Neuroscience: Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells
Toxins that target genes have deleterious effects on developing brains. In this article, pregnant mice are injected with genetic labeling agents…
Biology: Temporal Tracking of Cell Cycle Progression Using Flow Cytometry
10.11: Biology: Temporal Tracking of Cell Cycle Progression Using Flow Cytometry
Study of the cell cycle requires synchronization which can have detrimental effects and confound the results. The method presented here labels…
Genetics: Studying Cell Cycle-regulated Gene Expression
10.12: Genetics: Studying Cell Cycle-regulated Gene Expression
The study of cell-cycle dependent gene expression is important for understanding it’s role in disease. In this article, two…