Chapter 10

Cell Cycle and Division

What is the Cell Cycle?
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two…
Genomic DNA in Prokaryotes
10.2: Genomic DNA in Prokaryotes
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the…
Binary Fission
10.3: Binary Fission
Fission is the division of a single entity into two or more parts, which regenerate into separate entities that resemble the original. Organisms in…
Genomic DNA in Eukaryotes
10.4: Genomic DNA in Eukaryotes
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside…
Interphase
10.5: Interphase
The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of…
Mitosis and Cytokinesis
10.6: Mitosis and Cytokinesis
In eukaryotic cells, the cell's cycle—the division cycle—is divided into distinct, coordinated cellular processes that include cell…
Positive Regulator Molecules
10.7: Positive Regulator Molecules
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated. Internal…
Negative Regulator Molecules
10.8: Negative Regulator Molecules
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a…
Neuroscience: Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells
10.10: Neuroscience: Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells
Toxins that target genes have deleterious effects on developing brains. In this article, pregnant mice are injected with genetic labeling agents…
Biology: Temporal Tracking of Cell Cycle Progression Using Flow Cytometry
10.11: Biology: Temporal Tracking of Cell Cycle Progression Using Flow Cytometry
Study of the cell cycle requires synchronization which can have detrimental effects and confound the results. The method presented here labels…
Genetics: Studying Cell Cycle-regulated Gene Expression
10.12: Genetics: Studying Cell Cycle-regulated Gene Expression
The study of cell-cycle dependent gene expression is important for understanding it’s role in disease. In this article, two…