Joost Verhaagen Laboratory for Regeneration of Sensorimotor Systems, Netherlands Institute for Neuroscience Royal Netherlands Academy of Arts and Sciences (KNAW) Biography Publications Institution JoVE Articles Joost Verhaagen has not added a biography. If you are Joost Verhaagen and would like to personalize this page please email our Author Liaison for assistance. Publications Gene-expression Profiling of Individuals Resilient to Alzheimer's Disease Reveals Higher Expression of Genes Related to Metallothionein and Mitochondrial Processes and No Changes in the Unfolded Protein Response Acta Neuropathologica Communications. Apr, 2024 | Pubmed ID: 38664739 The Concept of Resilience to Alzheimer's Disease: Current Definitions and Cellular and Molecular Mechanisms Molecular Neurodegeneration. Apr, 2024 | Pubmed ID: 38589893 Improving Adeno-associated Viral (AAV) Vector-mediated Transgene Expression in Retinal Ganglion Cells: Comparison of Five Promoters Gene Therapy. Jun, 2023 | Pubmed ID: 36635457 Erratum To: The Jun-dependent Axon Regeneration Gene Program: Jun Promotes Regeneration over Plasticity Human Molecular Genetics. Apr, 2022 | Pubmed ID: 35166771 The Jun-dependent Axon Regeneration Gene Program: Jun Promotes Regeneration over Plasticity Human Molecular Genetics. Apr, 2022 | Pubmed ID: 34718572 Chondroitin 6-sulphate is Required for Neuroplasticity and Memory in Ageing Molecular Psychiatry. Oct, 2021 | Pubmed ID: 34272488 Optimization of Adeno-associated Viral Vector-mediated Transduction of the Corticospinal Tract: Comparison of Four Promoters Gene Therapy. Feb, 2021 | Pubmed ID: 32576975 Cerebellar Plasticity and Associative Memories Are Controlled by Perineuronal Nets Proceedings of the National Academy of Sciences of the United States of America. Mar, 2020 | Pubmed ID: 32152108 Enhanced Regeneration and Reinnervation Following Timed GDNF Gene Therapy in a Cervical Ventral Root Avulsion Experimental Neurology. Nov, 2019 | Pubmed ID: 31425689 Transcriptome Analysis of Normal-appearing White Matter Reveals Cortisol- and Disease-associated Gene Expression Profiles in Multiple Sclerosis Acta Neuropathologica Communications. Apr, 2019 | Pubmed ID: 31023360 Mesenchymal Stem Cell-Macrophage Choreography Supporting Spinal Cord Repair Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jul, 2018 | Pubmed ID: 29728851 Integrins Promote Axonal Regeneration After Injury of the Nervous System Biological Reviews of the Cambridge Philosophical Society. Aug, 2018 | Pubmed ID: 29446228 Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29188502 Overexpression of ATF3 or the Combination of ATF3, C-Jun, STAT3 and Smad1 Promotes Regeneration of the Central Axon Branch of Sensory Neurons but Without Synergistic Effects Human Molecular Genetics. Dec, 2015 | Pubmed ID: 26385639 A Comparative Morphological, Electrophysiological and Functional Analysis of Axon Regeneration Through Peripheral Nerve Autografts Genetically Modified to Overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF Experimental Neurology. Nov, 2014 | Pubmed ID: 25128265 Understanding the Neural Repair-promoting Properties of Olfactory Ensheathing Cells Experimental Neurology. Nov, 2014 | Pubmed ID: 24842489 Targeted Ablation of Crb2 in Photoreceptor Cells Induces Retinitis Pigmentosa Human Molecular Genetics. Jul, 2014 | Pubmed ID: 24493795 Gene Therapy Approaches to Enhance Regeneration of the Injured Peripheral Nerve European Journal of Pharmacology. Nov, 2013 | Pubmed ID: 23872403 Phenotypic Characterization of Retinoic Acid Differentiated SH-SY5Y Cells by Transcriptional Profiling PloS One. 2013 | Pubmed ID: 23724009 Modeling Early Parkinson's Disease Pathology with Chronic Low Dose MPTP Treatment Restorative Neurology and Neuroscience. 2013 | Pubmed ID: 23271419 Cortical Beta Amyloid Protein Triggers an Immune Response, but No Synaptic Changes in the APPswe/PS1dE9 Alzheimer's Disease Mouse Model Neurobiology of Aging. May, 2013 | Pubmed ID: 23245294 Molecular Target Discovery for Neural Repair in the Functional Genomics Era Handbook of Clinical Neurology. 2012 | Pubmed ID: 23098739 Noninvasive Bioluminescence Imaging of Olfactory Ensheathing Glia and Schwann Cells Following Transplantation into the Lesioned Rat Spinal Cord Cell Transplantation. 2012 | Pubmed ID: 22449606 Gene Therapy for the Peripheral Nervous System: a Strategy to Repair the Injured Nerve? Current Gene Therapy. Apr, 2011 | Pubmed ID: 21291360 In Vivo Targeting of Subventricular Zone Astrocytes Progress in Neurobiology. Sep, 2010 | Pubmed ID: 20441785 Comparison of AAV Serotypes for Gene Delivery to Dorsal Root Ganglion Neurons Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2010 | Pubmed ID: 20179682 Analysis of Gene Expression in Parkinson's Disease: Possible Involvement of Neurotrophic Support and Axon Guidance in Dopaminergic Cell Death Brain Pathology (Zurich, Switzerland). Jan, 2009 | Pubmed ID: 18462474 Author Spotlight: Advancing Gene Therapy with High-Yield AAV Vectors Through HEK293 Suspension Cell Cultivation Kimberly L. Pietersz1, Paul J.H. Nijhuis1, Matthijs H.M. Klunder1, Joëlle van den Herik1, Barbara Hobo1, Fred de Winter1, Joost Verhaagen1,2 1Laboratory for Regeneration of Sensorimotor Systems, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), 2Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam JoVE 66532 Neuroscience
Author Spotlight: Advancing Gene Therapy with High-Yield AAV Vectors Through HEK293 Suspension Cell Cultivation Kimberly L. Pietersz1, Paul J.H. Nijhuis1, Matthijs H.M. Klunder1, Joëlle van den Herik1, Barbara Hobo1, Fred de Winter1, Joost Verhaagen1,2 1Laboratory for Regeneration of Sensorimotor Systems, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), 2Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam JoVE 66532 Neuroscience